Imperial Collage Healthcare

Anti-Phospholipase A2 Receptor Antibody (anit-PLA2R)

Test Background

The anti-PLA2R (IgG) antibody assay is a quantitative enzyme immunoassay (ELISA) for the in vitro measurement of IgG antibodies targeted against the M-type-phospholipase A2 receptor (PLA2R) on renal podocytes in patient sera.

Clinical Indications

The anti-PLA2R test is useful in the diagnosis and monitoring of primary membranous glomerulonephritis

Anti-PLA2R antibodies are positive in 75-80% of cases of primary membranous glomerulonephritis.

There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression

Reference Range
<14 RU/ml (negative)

Sample Required
Serum - 5ml Gel SST (RUST TOP)

Sample Collection

Samples should be transported at room temperature to the laboratory within 2-3 days from collection

Sample Volume
Minimum 1ml Serum


Room temperature

Turnaround Time
14 days


This test is currently unaccredited due to a recent change in platform (manual to automation).


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