Imperial Collage Healthcare

CK Isoenzymes

Test Background
The human enzyme creatine kinase is composed of three isoenzymes MM, MB & BB.

Clinical Indications
A CKMB > 5 % may be indicative of acute myocardial infarction. Troponin is widely available as a sensitive and specific marker of cardiac damage and CK isoenzyme analysis is now rarely used for this purpose. However, it is useful in cases of persistently raised total CK. It can be used to determine possible heart or muscle pathology and also to exclude the presence of Macro CK (Type 1: immunoglobulin complex, and Type 2: mitochondrial CK).

Reference Range

Sample Required

Sample Volume
100 µL


Stable at 2-8oC  for 72 hours. Please freeze pending dispatch for analysis.
Sample can be sent by first class post.

Turnaround Time

4-6 Weeks


Please include the Total CK result on the request if available.

Specimens containing inhibitors of CK activity e.g. heparin, EDTA, citrate, fluoride or iodoacetate are unsuitable.

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