Imperial Collage Healthcare

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5α-Dihydrotestosterone (5α-DHT)

Test Background
5α-Dihydrotestosterone (5α-DHT) is the most potent androgenic steroid and is the main intracellular androgen. In target tissues such as the prostate, seminal vesicles and skin, testosterone is reduced to 5α-DHT by the enzyme 5α-reductase.

Clinical Indications

Its measurement (and the ratio of DHT to testosterone) is useful to identify end organ insensitivity to androgens due to 5α-reductase deficiency. This can be done in a random sample or in response to an hCG stimulation test.

Reference Range

Females up to 1 nmol/L
Males 1 – 3 nmol/L

Sample Required
Serum (red top, plain tube) or plasma

Sample Volume
0.5 mL


Stable at 2-8oC for 24 hours. Please freeze pending dispatch for analysis.

Send to lab frozen.

Turnaround Time

4 weeks

Grossly haemolysed samples are unsuitable for this assay.

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