Imperial Collage Healthcare

Cortisol binding globulin

Test Background
CBG is the major binding protein for cortisol, with a smaller amount bound to albumin, and transports cortisol in the blood in an inactive form. Elevated CBG levels are seen  in pregnancy and on oral contraceptive or oestrogen treatment. Low CBG levels may be observed in hyperinsulinaemic states, nephotic syndrome and chronic liver disease.

Clinical Indications

Interpretation of dynamic function tests of the HPA axis
Investigation of abnormal unexplained cortisol concentrations.

Reference Range

Adult male     27.1-52.3 mg/L
Adult female   31.0-53.4 mg/L

Sample Required

Sample Volume
0.5 mL


Stable at 2-8oC for 48 hours. Please freeze pending dispatch for analysis.

Send to lab frozen.

Turnaround Time

6 weeks


Mainly used for research purposes.

Grossly haemolysed samples are unsuitable for this assay. 

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