Imperial Collage Healthcare

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HIV-1 Resistance (Protease and reverse transcriptase)

Test Background

Decreased susceptibility of HIV-1 to antiretroviral drugs is usually associated with sequence changes in the viral genome (genotypic drug resistance). Detection of these mutations in the viral genome can be used to predict accurately the susceptibility of the virus to all currently licensed antiretroviral drugs and thus can be used to optimise the use of antiretroviral treatment on an individual patient basis. The routine test for resistance to protease and reverse-transcriptase inhibitors generates a sequence covering the resistance associate sites in the protease and the reverse-transcriptase gene.

Clinical Indications

Baseline and/or when failing therapy

Reference Range
Please contact the laboratory.

Sample Required
Plasma or Serum

Sample Volume

Turnaround Time
14 days


Must have quantifiable HIV-1 viral load. 

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