Imperial Collage Healthcare

Scl-70 antibodies

Test Background
This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Antibodies to DNA-topoisomerase (Scl-70) are found in patients with scleroderma (~25 %) and are usually associated with the progressive systemic sclerosis subset.

Clinical Indications
Scleroderma Systemic sclerosis

Reference Range


Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
5 days

Filter by A-Z

Select a test from the left to view more details.