Imperial Collage Healthcare

Neuronal antibodies

Test Background
Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterised by subacute cerebellar ataxia, specific tumour types and (often) associated anti-neuronal antibodies (of which there have been 9 characterised.) Initial screen includes Yo and Ri; the following antibodies are available.


Staining pattern

Associated tumours

Yo (PCA-1)

Purkinje cell cytoplasm and axons

Ovary, breast

Ma (Ma1)

Neuronal nuclei

Various cancer

Ta (Ma2)

Neuronal nuclei, perikaryon

Testicular cancer

Hu (ANNA1)

Nuclei of both central and peripheral neurones


Ri (ANNA2)

Nuclei of central neurones

Breast, SCLC, gynaecological


Oligodendrocytes cytoplasm

SCLC, thymoma


Central presynaptic terminals

Breast cancer, SCLC

Clinical Indications
Please include full clinical details to ensure the most appropriate antibodies are tested.

Reference Range

Sample Required
RST (rust top), Gel SST (yellow top), Can also be performed on CSF

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
14 days

This test is currently unaccredited due to a recent change in platform. 

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