Imperial Collage Healthcare

MuSK antibodies

Test Background
Antibodies to the muscle-specific receptor tyrosine kinase are involved in the pathogenesis of acetylcholine receptor (ACR) antibody-negative myasthenia gravis. Testing for these antibodies should be considered in the 20 % of patients with clinical symptoms of myasthenia gravis who do not demonstrate antibodies to the ACR.

Clinical Indications
Diagnosis of myasthenia gravis with or without equivocal anti-AChR findings

Reference Range

Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
28 days

Not currently performed in house; this test is referred to the Department of Immunology at the Churchill Hospital in Oxford.

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