Test Background Anti-mitochondrial antibodies (AMA), which are directed against components of mitochondrial dehydrogenase complexes, are detected by indirect immunofluorescence using mouse liver/kidney/stomach (LKS) substrate. Positive results are then tested by liver immunoblot for confirmation.
Clinical Indications Mitochondrial antibodies are associated with primary biliary cirrhosis AMA are also detected in patients with chronic hepatitis C infection and systemic sclerosis
Reference Range Negative
Sample Required RST (rust top)
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 7 days
Notes This test is currently unaccredited due to a recent change in platform.