Imperial Collage Healthcare

Jo-1 antibodies

Test Background
This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Jo-1 antibodies are detected in patients with myositis, especially in combination with pulmonary fibrosis.

Clinical Indications
Suspected autoimmune-mediated connective tissue disorders Suspected myositis

Reference Range


Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
14 days

This test is currently unaccredited due to a recent change in platform/assay.

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