Imperial Collage Healthcare

Intrinsic factor antibodies

Test Background
Antibodies against intrinsic factor are present in 50-60 % of patients with pernicious anaemia. Their presence may pre-date the development of B12 deficiency. It is recommended to also check vitamin B12 levels.

Clinical Indications
Differential diagnosis of pernicious anaemia (autoimmune causes are not refractory to dietary B12 supplementation).

Reference Range

Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
14 days


Due to a change in platform, the laboratory is not currently accredited for this test.

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