Imperial Collage Healthcare

Ganglioside antibodies

Test Background
There is a wide range of ganglioside antibodies, which includes IgG and IgM antibodies to GM1, GM2, GD1A, GD1B and GQ1b. GM1 antibodies are seen in Guillain-Barré syndrome. GQ1b antibodies are seen in the Miller Fisher variant.

Clinical Indications
Suspected Guillain-Barré syndrome Chronic demyelinating polyneuropathy Multifocal motor neuropathy

Reference Range
<500 = negative

Sample Required
RST (rust top), Can also be performed on CSF

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
28 days


Not currently performed in house; this test is referred to Institute of Neurology, Queens Square. 

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