Imperial Collage Healthcare

DNA double stranded antibodies, quantitative


Test Background

Detection and quantitation of DNA is useful in the diagnosis of SLE and is more specific than the antinuclear antibody test. It is positive in about 50 % of cases of SLE. Low titres of anti-dsDNA can be present in normal individuals, and in patients with Sjögren's syndrome, rheumatoid arthritis and other connective tissue and autoimmune disorders. The presence of anti-dsDNA tends to correlate with lupus nephritis, and the anti-dsDNA level often, but not always, correlates with disease activity in SLE.

 

 


Clinical Indications
Diagnosis of SLE Monitoring of SLE


Reference Range

<4 IU/mL

Indeterminate 5 – 10 IU/mL

Positive > 10 IU/mL


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
14 days


Notes
This test is currently unaccredited due to a recent change in platform/assay.


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