Test Background Anti-adrenal antibody results are positive in 60-70 % of patients with idiopathic Addison’s disease. Antibodies against adrenal cortex are associated with primary adrenal failure in up to 50 % of patients with Addisonian adrenal insufficiency. Positive antibodies can, however, be an incidental finding or predate the development of hypoadrenalism. Anti-adrenal antibodies are also present in 28 % of patients with idiopathic hypothyroidism and 7 % of patients with Hashimoto’s disease. Positive antibodies may also be associated with gonadal failure.
Clinical Indications Raised titres in adrenocortical insufficiency due to an autoimmune disorder (Addison's Disease).
Reference Range Negative
Sample Required RST (rust top)
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 14 days
Notes This test is currently unaccredited due to a recent change in platform.