Imperial Collage Healthcare

Urinary steroid profile

Test Background
Requested for investigations of suspected steroid hormone-secreting tumours, causes of virilisation, ie. enzyme deficiencies that cause a masculine appearance, or in cases of apparent electrolyte imbalance with or without hypertension.

Clinical Indications
Diagnosis of CAH (cliteromegaly/ambiguous genitalia of infants or delayed puberty/deranged electrolyte balance in late-onset CAH) Diagnosis of adrenal hypofunction Suspected aldosterone resistance/insensitivity Diagnosis of adrenal tumours (common tumours secrete DHEAS, 11ß-hydroxyandrostenedione and pregnenolone)

Reference Range
See report

Sample Required
24 hour urine collection Spot urine for babies/children

Sample Volume
24 hour urine collection 5 mL for babies/children

Turnaround Time
Up to 6 weeks

Not currently performed in house; this is a referred test. Request should be made or sanctioned by a consultant endocrinologist.

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