Test Background Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus. Sirolimus is an immunosuppressant, structurally similar to tacrolimus, which is indicated for the prophylaxis of organ rejection in kidney allograft recipients (initially in combination with ciclosporin and corticosteroid, then with corticosteroid only). Sirolimus regimens are generally significantly more effective than azathioprine at reducing the incidence of acute rejection.
Clinical Indications Therapeutic drug monitoring for patients undergoing immunosuppression therapy following transplantation, to achieve the desired therapeutic window in view of typically idiosyncratic drug interactions/cross-reactions.
Reference Range See report
Sample Required EDTA (lavender top)
Sample Volume 2mL (Timed see below)
Within 7 days from receipt of sample into the Leslie Brent Laboratory
Notes The sample should be taken just before the subsequent dose (trough level) and at a constant interval; 24h
Tests performed Wednesdays Only
Not currently performed in house; this is a referred test. Please send specimens directly to the Leslie Brent Laboratory, West London Renal and Transplant Centre, Hammersmith Hospital 020 331 36637 Clinical Biochemistry will forward any specimens received to the Leslie Brent Laboratory.