Iron is routinely measured in serum/plasma to assess iron stores and is rarely measured in urine. However, urine iron measurements can be used to monitor chelation therapy of patients with iron overload. In these cases the chelating agents interfere in dye-binding assays, so routine automated chemistry tests cannot be used. This method uses ICP-MS, which does not suffer from chelating agent interference.
Measurement of urinary iron excretion during chelation therapy