Imperial Collage Healthcare


Test Background
Androstenedione, produced in the adrenal glands and gonads, is a precursor to the androgen testosterone and the oestrogens oestrone and oestradiol. Androstenedione may accumulate in CAH due to 21-hydroxylase or 11β­ hydroxylase deficiency or in PCOS through increased testosterone turnover. Its secretion may also be elevated by ovarian and adrenal tumours.

Clinical Indications
Monitoring treatment of patients with CAH Diagnosis of 17-hydroxysteroid dehydrogenase deficiency. May be useful in differential diagnosis of hyperandrogenism Limited use in diagnosis of CAH, inappropriate to investigations of PCOS

Reference Range
0-9 nmol/L
<3 nmol/L prior to adrenarche

Sample Required
Serum (red top)

Sample Volume
0.5 mL


Stable at 2-8oC for 72 hours. Please freeze pending dispatch for analysis.

Sample can be sent by first class post.

Turnaround Time
10 days


Grossly haemolysed samples are unsuitable for this assay.

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