Imperial Collage Healthcare

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11-Deoxycortisol (11DOC)

Test Background
11DOC and 11-deoxycorticosterone accumulate in the presence of a functional or cumulative 11β hydroxylase deficiency a cause of congenital adrenal hyperplasia (CAH). This is one of the less common presentations of CAH. Measured also in the overnight metyrapone test for assessment of hypoadrenalism.

Clinical Indications
Clinical picture of CAH with any of the following: overnight metyrapone test, hypervolaemic hypernatraemia with or without hypertension or hypokalaemia

Reference Range
See report

Sample Required
Serum (red top)

Sample Volume
0.5 mL

Turnaround Time
Up to 6 weeks

17α-hydroxyprogesterone should be measured first. Not currently performed in house; this is a referred test.

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