Imperial Collage Healthcare

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17α-Hydroxyprogesterone (17OHP)


Test Background
17OHP is a precursor of cortisol, the major glucocorticoid synthesised in the adrenal cortex. Congenital adrenal hyperplasia (CAH) results in excessive ACTH secretion due to impairment in the synthesis of cortisol. A variety of enzyme defects in the pathway to cortisol synthesis have been identified, of which the most common is a 21-hydroxylase deficiency; 17OHP is the substrate for this enzyme. The serum 17OHP levels are significantly elevated in this condition.


Clinical Indications
Ambiguous neonatal genitalia (female infants) ’Salt-wasting’ clinical symptoms (dehydration, vomiting, listlessness) Precociousness or failure of puberty Virilisation


Reference Range

0-3 months: <10nmol/L
3 months-5 years: 0-2.5 nmol/L
5-11 years: 0-3.0 nmol/L
Over 11 years: <9.6 nmol/L


Sample Required
Serum (red top)


Sample Volume
0.5 mL


Transport/Storage

Stable at 2-8oC for 72 hours. Please freeze pending dispatch for analysis.

Sample can be sent by first class post.


Turnaround Time
10 days


Notes

Grossly haemolysed samples are unsuitable for this assay.


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