Test Background Detection of human T lymphotropic antibodies. HTLV-I and HTLV-II are closely related human type C retroviruses. HTLV-I has been aetiologically associated with neoplastic conditions and a variety of demyelinating neurological disorders, including: adult T-cell leukaemia (ATL), tropical spastic paraparesis (TSP), and/or HTLV-I-associated myelopathy (HAM), and, more recently, HTLV-I-associated polymyositis, arthritis and infective dermatitis. Association of HTLV-II with leukaemia pathogenesis is not established, however, there is some evidence of an association with a neurodegenerative disease similar to HAM/TSP and occasionally also with lymphoproliferative disease. Transmission of both HTLV-I and HTLV-II is by sexual contact, exposure to infected cellular blood components by transfusion or intravenous drug use, or perinatally by breastfeeding.
Clinical Indications Part of the screening profile for patients undergoing fertility treatment. Please include all relevant clinical history.
Reference Range See report
Sample Required RST (rust top)
Sample Volume 5 mL
3 days (Confirmation: non-negatives up to 10 days)
Notes The laboratory is currently unaccredited for this test due to a change in platform.