Imperial Collage Healthcare

Encephalitis Antibodies

Test Background

Voltage gated potassium channel antibodies are seen in neuromyotonia.
NMDA-R, LGI1 , CASPR, AMPA1/2, GABAB antibodies.


Clinical Indications
Presentation of muscle cramps, myotonia-like symptoms, excessive sweating, myokymia and fasciculations Diagnosis of Morvan’s syndrome (sleep disorders, memory loss and confusion)

Reference Range

Normal = 0 - 69 pmol/L

Equivocal = 70-130 pmol/L

Positive = >130 pmol/

Sample Required
RST (rust top), Gel SST (yellow top), Can also be performed on CSF

Sample Volume
5-10 mL (2 mL serum)

Turnaround Time
28 days


Not currently performed in house; this test is referred to the University Hospital, Birmingham.

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