Imperial Collage Healthcare

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Donath-Lansteiner test (for paroxysmal cold haemoglobinuria)

Test Background
Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by cold-reacting immunoglobulins. It primarily affects children and tends to cause quite severe, but transient, disease.

Clinical Indications
Presence of a biphasic antibody that binds to the red cells in the cold and lyses the red cell at 37 °C.

Reference Range

Not applicable

Sample Required
EDTA (lavender top)

Sample Volume
4 mL for paediatrics6 mL for adults

Turnaround Time
Dependent on clinical requirement. Contact the laboratory to discuss further.

This test is referred to the NHS Blood and Transplant service

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