Imperial Collage Healthcare

Tyrosine Phosphatase/ Insulinoma-associated Antigen 2 (Anti-IA2 ELISA)


Test Background
Insulinoma-associated antigen 2 (IA2) -  detected in 50-70% of children and 30-50% adults with a newly apparent diabetes mellitus type 1, levels decline with increasing age.
In persons without diabetes, they have a high predictive value for the individual risk of type 1 diabetes. IA2 antibodies are most frequent in patients with HLA DR4/HLA DQ8 genotype.


Clinical Indications
Suspected type 1 diabetes (T1D)


Reference Range
The normal range for this assay is <10 IU/ml


Sample Required
Serum sample


Sample Container
Rust top whole blood tube


Sample Collection
whole blood


Sample Volume
5-10 mL (1 mL serum)


Transport/Storage
Transported at room temperature. Once serum has been extracted, sample is stored at 4-6oC


Turnaround Time
14 days


Notes

This is newly implemented and the laboratory is currently awaiting accreditation for this test.


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