Imperial Collage Healthcare

Von Willebrand Factor Multimer Analysis

Test Background

VWF Multimer Analysis is a second line test in the investigation of Von Willebrand Disease (VWD) and provides further information where the disease type or subtype is unclear. Multimer analysis is performed by SDS-PAGE gel electrophoresis, which allows for the visual assessment of various sizes of VWF multimers. Of particular clinical significance are the high molecular weight multimers, which possess significant haemostatic potential and where absent are suggestive of type II VWD.
Results should be interpreted with VWF Antigen, VWF Ristocetin cofactor activity, Collagen binding assay and Factor VIII level.

Clinical Indications
Investigation of Von Willebrand Disease (VWD)

Reference Range
For advice with interpretation please contact the lab or haematology clinical team

Sample Required
2.7 mL sodium citrate (pale blue top) adults 1.8 mL sodium citrate (pale blue top) paediatrics

Turnaround Time
12 weeks


All requests must be discussed with and approved by the haematology clinical team.

Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed

Von Willebrand Factor multimers are performed by the Royal Free Hospital laboratory

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