Imperial Collage Healthcare

Apixaban


Test Background
Apixaban is a direct oral anticoagulant (DOAC) which exerts its anticoagulant effect through its ability to directly inhibit Coagulation Factor X. Plasma Apixaban levels are measured in mass concentration by chromogenic anti-Xa assay using drug-specific calibrators.


Clinical Indications

Recommended as an option for (NICE Guidelines 2016 – KTT16)

• Prevention of VTE after elective hip or knee replacement
• Treatment and secondary prevention of DVT and/or PE
• Prevention of stroke and systemic embolism in people with non-valvular AF

DOAC monitoring is not generally required; however measurement may be useful where clearance is compromised or where patients are actively bleeding.


Reference Range

BCSH Guidelines (2014) Measurement of non-coumarin anticoagulants and their effects on tests of Haemostasis

:


Dose                             Peak (mean and range)      Trough (mean and range)
Apixaban 2.5 mg bd       62 ng/mL (CV 37%)           21 ng/mL (CV 17%)
Apixaban 5 mg bd         128 ng/mL (CV 10%)          50 ng/mL (CV 20%)


Sample Required
4.5 mL sodium citrate (pale blue top) adults 1.8 mL sodium citrate (pale blue top) paediatrics


Turnaround Time
<24 hours (core hours)


Notes
Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed

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