Imperial Collage Healthcare

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Vedolizumab Trough level


Test Background
Vedolizumab (Entyvio©) is a humanised IgG1 antibody which inhibits the action of the mucosal trafficking α4β7 integrin and prevents migration of inflammatory T cells to the gut. Vedolizumab levels are measured in serum taken from patients just before an infusion (trough) using an indirect ELISA coated with α4β7 integrin


Clinical Indications
For the monitoring of drug trough levels in IBD patients treated with Vedolizumab


Reference Range
Results are reported between 0.8µg/ml and 96.0µg/ml.  In the induction phase of the Entyvio© clinical trials week 6 trough levels were higher in responders than non-responders and higher trough levels were associated with increased mucosal healing in UC patients.


Sample Required
Serum


Sample Container
Rust Top Vacutainer


Sample Collection
Samples should be taken just before the next infusion of drug (trough)


Sample Volume
0.5ml


ransport/Storage
Transportation at room temperature/ first class post is adequate. Storage at 4 degrees or -20 for long term.


Turnaround Time
4 weeks


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