Imperial Collage Healthcare

Serum Tryptase


Test Background
Measurement of serum tryptase levels is used to confirm mast cell degranulation.
The test does not distinguish between anaphylactic and anaphylactoid reactions.
Tryptase levels may be significantly raised after an acute reaction that involves mast cell degranulation and then return to within normal range.
In order to assess the significance of an elevated serum Tryptase result, it is important to take a baseline samples when the patient has fully recovered.
For Anaphylactic/Anaphylactoid reactions (including anaesthetic reactions) take a samples
•  Within 1 hour of a suspected anaphylactic event.
•  Between 2-4  hours post event.
•  After 24 hours post event.


Clinical Indications
Investigation of anaphylaxis/anaphilactoid reactions and mastocytosis


Reference Range

2 – 14µg/L


Sample Required
Rust/Yellow top


Sample Volume
Minimum 5ml.


Turnaround Time
14 Days


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