Troponin I (TnI) is a regulatory subunit of the troponin complex and plays an integral role in the regulation of muscle contraction. Clinical studies have demonstrated the release of cardiac TnI (cTnI) into the blood stream within hours following myocardial infarction (MI) or ischaemic damage. Elevated levels of cTnI (above the values established for non-MI specimens) are detectable in serum within 2 hours after the onset of chest pain, reach peak concentrations in approximately 8-28 hours, and remain elevated for 3-10 days following MI.
Clinical Indications Diagnosis of MI
Risk stratification of patients with acute coronary syndromes, including unstable angina and non-ST elevation, with respect to relative risk of mortality, MI or increased probability of ischaemic events
Male <35 ng/L
Female <16 ng/L
Sample Required EDTA (lavender top)
Sample Volume 0.5 mL
Turnaround Time 1 day
Notes Levels peak at about 12 hours post MI. Can take 5-7 days to return to normal.