FISH involves the application of fluorescent DNA probes specific to genes or genetic regions of interest that highlight abnormalities involving these regions.
FISH for the detection of genetic imbalances or rearrangements conferring prognostic value, often in relation to response to targeted therapy, is a key aspect of the management of an increasing number of tumours of solid tissue.
1p/19q co-deletion is associated with both chemosensitivity and improved prognosis in oligodendrogliomas. The co-deletion is detected using FISH probes for these two genetic regions.
Sample Required See notes section
Turnaround Time 7 days from receipt of tissue section
FISH for genetic markers in solid tumours is performed on sections from FFPE tissue. If a biopsy has been sent to Imperial for histological investigation it is usually possible to obtain sections for FISH from unused material. If not, please send a paraffin embedded block or FFPE tissue sections.