Imperial Collage Healthcare

HIV-1 Resistance (Integrase)


Test Background

This HIV-1 Integrase Genotype test is designed to detect mutations associated with resistance to raltegravir dolutegravir or elvitegravir, the only FDA-approved HIV integrase strand transfer inhibitors (INSTIs) currently available. These drugs represent a class of antiretrovirals that inhibit the catalytic activity of integrase and thereby prevent formation of the HIV provirus required for viral propagation.


Integrase resistance testing is recommended for patients experiencing virologic failure while taking these integrase inhibitors. It can also be considered as a supplement to standard baseline genotypic resistance testing if transmitted resistance to either drug is suspected.


Clinical Indications

Baseline and/or when failing therapy


Reference Range

Contact Laboratory


Sample Required
EDTA whole blood


Sample Volume
10mL


Turnaround Time
14 days


Notes

Must have quantifiable HIV-1 viral load. 

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