Imperial Collage Healthcare

Scl-70 antibodies


Test Background
This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Antibodies to DNA-topoisomerase (Scl-70) are found in patients with scleroderma (~25 %) and are usually associated with the progressive systemic sclerosis subset.


Clinical Indications
Scleroderma Systemic sclerosis


Reference Range

Negative


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
5 days


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