Test BackgroundIgG antibody levels to Streptococcus pneumoniae are requested as part of immune deficiency screen for patients with recurrent or opportunistic infections, and should be done alongside tetanus toxoid antibodies. This test measures antibodies to Pneumovax serotypes as occurring in vaccine containing a mix of 23 capsular serotypes of Streptococcus pneumoniae (polysaccharide antigens). Antibodies measure the T-cell independent immune response. However, this response requires a mature immune system, hence normal values are age related and the test is not indicated in patients less than 2 years of age. A good overall response may not indicate protection to individual serotypes.
Clinical Indications Recurrent infection Primary immunodeficiency
Sample Required RST (rust top)
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 28 days
Not available to order on PI. Must be consultant request
Not currently performed in house; this test is referred to the Immunology Department in Cambridge