Imperial Collage Healthcare

Pneumococcal antibodies


Test Background
IgG antibody levels to Streptococcus pneumoniae are requested as part of immune deficiency screen for patients with recurrent or opportunistic infections, and should be done alongside tetanus toxoid antibodies. This test measures antibodies to Pneumovax vaccine containing a mix of 23 capsular serotypes of Streptococcus pneumoniae (polysaccharide antigens). Antibodies measure the T-cell independent immune response. However, this response requires a mature immune system, hence normal values are age related and the test is not indicated in patients under 2 years of age. A good overall response may not indicate protection to individual serotypes.


Clinical Indications
Recurrent infection Primary immunodeficiency


Reference Range

Adult reference value
Good Level >39 U/mL

Paediatric reference value
*0-1 year              Good level >14 U/ml
1-<2 years            Good level >14 U/ml
2-<3 years            Good level >19 U/ml
3-<4 years            Good level >29 U/ml
4-<10 years          Good level >44 U/ml
10-<18 years        Good level >39 U/ml


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
14 days


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