Imperial Collage Healthcare

Neuronal antibodies


Test Background
Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterised by subacute cerebellar ataxia, specific tumour types and (often) associated anti-neuronal antibodies (of which there have been 9 characterised.) Initial screen includes Yo and Ri; the following antibodies are available.

Antibody

Staining pattern

Associated tumours

Yo (PCA-1)

Purkinje cell cytoplasm and axons

Ovary, breast

Ma (Ma1)

Neuronal nuclei

Various cancer

Ta (Ma2)

Neuronal nuclei, perikaryon

Testicular cancer

Hu (ANNA1)

Nuclei of both central and peripheral neurones

SCLC

Ri (ANNA2)

Nuclei of central neurones

Breast, SCLC, gynaecological

CV2/CRMP5

Oligodendrocytes cytoplasm

SCLC, thymoma

Amphiphysin

Central presynaptic terminals

Breast cancer, SCLC


Clinical Indications
Please include full clinical details to ensure the most appropriate antibodies are tested.


Reference Range

Negative


Sample Required
RST (rust top), Gel SST (yellow top), Can also be performed on CSF


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
14 days


Filter by A-Z

Select a test from the left to view more details.