Imperial Collage Healthcare

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Myeloperoxidase antibodies


Lab Code : MPO


Test Background
p-ANCAs are directed against myeloperoxidase and are generally associated with microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS). See neutrophil cytoplasmic antibodies (ANCA).


Clinical Indications
Skin rashes with or without pain (cutaneous vasculitis) Systemic vasculitis General (protean) symptoms, such as feeling unwell, weight loss, night sweats, joint pains Haematuria/proteinuria (kidney-associated) Haemoptysis, difficulty in breathing (lungs) Muscle weakness/numbness of extremities (microvascular) Abdominal pain (gut) In addition to acute heart and brain symptoms when these organs are implicated


Reference Range

<3.5 IU/mL = Neg
3.5 – 5 IU/mL= Equivocal
>3.5 IU/mL = Pos


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
5 days


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