Test Background Antibodies to the muscle-specific receptor tyrosine kinase are involved in the pathogenesis of acetylcholine receptor (ACR) antibody-negative myasthenia gravis. Testing for these antibodies should be considered in the 20 % of patients with clinical symptoms of myasthenia gravis who do not demonstrate antibodies to the ACR.
Clinical Indications Diagnosis of myasthenia gravis with or without equivocal anti-AChR findings
Reference Range Negative
Sample Required RST (rust top)
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 28 days
Notes Not currently performed in house; this test is referred to the Department of Immunology at the Churchill Hospital in Oxford.