Imperial Collage Healthcare

Mitochondrial antibodies

Test Background
Anti-mitochondrial antibodies (AMA), which are directed against components of mitochondrial dehydrogenase complexes, are detected by indirect immunofluorescence using mouse liver/kidney/stomach (LKS) substrate. Positive results are then tested by liver immunoblot for confirmation.

Clinical Indications

  • Mitochondrial antibodies are associated with primary biliary cirrhosis
  • AMA are also detected in patients with chronic hepatitis C infection and systemic sclerosis

Reference Range


Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
7 days

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