Imperial Collage Healthcare

Immunoglobulin-g subclasses (IgG1-4)


Test Background
Isolated IgG1 deficiency is almost always seen in association with reduced serum IgG levels. Patients with IgG2 deficiency who fail to make appropriate antibody responses to pneumococcus and other polysaccharide encapsulated micro-organisms have an increased risk of bacterial infection. There is no evidence that isolated IgG3 deficiency is associated with disease and up to 25 % of Caucasians have reduced or absent IgG4 levels.


Clinical Indications
Presentation of progressive and recurrent respiratory infection, multiple recurrent otitis media, severe pyogenic infection and ataxia telangiectasia.


Reference Range

Adults
IgG 1 : 3.2-10.2 g/L
IgG 2 : 1.2-6.6 g/L
IgG 3 : 0.2-1.9 g/L
IgG 4 : 0-1.3 g/L
Please note, values for children vary according to age.


Sample Required
RST (rust top)


Sample Volume
5-10 mL (2 mL serum)


Turnaround Time
14 days


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