Imperial Collage Healthcare

HLA-B*57:01


Clinical Indications

  • HLA-B*57:01 screening for abacavir hypersensitivity.
  • Most patients can safely take abacavir, however, a small number of patients – about 5 % – experience a severe side effect known as abacavir hypersensitivity. The most common symptoms are skin rash, fever, nausea, vomiting and diarrhea. This reaction can sometimes be very serious and in some cases can cause death. Patients who are HLA-B*57:01 positive are much more likely to have this reaction than patients who do not. Therefore, patients with the HLA-B*57:01 gene should not take abacavir. Approximately 5-8 % of Europeans, 1-2 % of Asians, and 2% of Africans have this gene.


Reference Range

Negative


Sample Required
EDTA (lavender top)


Sample Volume
5-10 mL


Turnaround Time
14 days


Notes
Samples must be sent via first class post or courier.

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