Imperial Collage Healthcare

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HLA high resolution typing

Test Background
Testing includes: • HLA high resolution class I typing • HLA high resolution class II typing

Clinical Indications
In unrelated donor bone marrow transplantation, HLA matching must be to the highest level possible. High resolution typing for HLA-A, -B and -C (class I) or HLA-DR, -DQ (and -DP) (for class II) resolves specificities to the allelic level. In certain situations it may be appropriate to type for the presence or absence of one or more specific HLA alleles. In particular, the possession of certain alleles is known to predispose individuals to various conditions and autoimmune diseases.

Reference Range
Interpretive report provided

Sample Required
EDTA (lavender top)

Sample Volume
20 mL

Turnaround Time
30 days

Samples must be sent via first class post or courier. In cases where HLA typing is used prognostically, or as a tool to aid diagnosis, it is essential that the request includes information on the suspected condition(s). High resolution typing is normally performed after basic or low resolution HLA typing, and the cost is therefore additional to the cost of basic typing. There is no test request code for high resolution typing; the test is performed based on clinical relevance or on request as discussed with the laboratory.

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