Test Background The laboratory employs a number of alternative assay systems with varying sensitivity and clinical significance. In most cases, routine screening will be performed using one, or a combination, of complement dependent cytotoxicity, flow cytometry or Luminex technology. Post transplant monitoring is usually performed using the Luminex Single Antigen (SA) analysis, a powerful technique used to detect the presence of donor-specific antibodies (DSA).
Clinical Indications Used for the detection and characterisation of lymphocytotoxic antibodies (HLA) in patients awaiting renal or pancreas transplant, or those who have received a transplant. It may also be used for haematology patients undergoing mismatched stem cell transplantation, to identify donor specific antibodies. For all recipients, patient antibody profiles are maintained by the laboratory.
Notes Samples must be sent via first class post or courier. It is important to record the sample date when requesting these tests. Please provide HIV and hepatitis B status. Results are held with the patient history, and are not routinely reported for individual samples.