Test Background There is a wide range of ganglioside antibodies, which includes IgG and IgM antibodies to GM1, GM2, GD1A, GD1B and GQ1b. GM1 antibodies are seen in Guillain-Barré syndrome. GQ1b antibodies are seen in the Miller Fisher variant.
Clinical Indications Suspected Guillain-Barré syndrome Chronic demyelinating polyneuropathy Multifocal motor neuropathy
Reference Range <500 = negative
Sample Required RST (rust top), Can also be performed on CSF
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 28 days
Not currently performed in house; this test is referred to Institute of Neurology, Queens Square.