Imperial Collage Healthcare

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Extractable nuclear (ENA) antibodies

Test Background
This test detects antibodies against a group of antigens in the nucleus and cytoplasm. ENA antibodies are useful in classifying clinical subsets of connective tissue diseases. The screen includes: anti-Ro (SS-A) and anti-La (SS-B) antibodies seen in Sjögren’s and SLE; anti-Sm antibody specific for SLE; anti-ribonucleoprotein (RNP) antibodies seen in mixed connective tissue disease; anti-Jo-1 (histidyl-tRNA synthetase) antibody seen in myositis and anti-Scl-70 (topoisomerase-1) antibody seen in scleroderma.

Clinical Indications
Suspected autoimmune-mediated connective tissue disorders ‘Speckled’ pattern observed on antinuclear antibody immunofluorescence

Reference Range
Negative Positive range: 0-40 AU/mL

Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
10 days screen 14 days specificities

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