Imperial Collage Healthcare

Enterocyte antibodies


Test Background
Autoimmune enteropathy is an entity reported primarily in infancy, resulting in intractable diarrhoea and associated with small bowel villous atrophy and the presence of circulating enterocyte antibodies. It is a multisystem disorder with a response, in many cases, to immunosuppressive therapy.


Clinical Indications

  • Differential diagnosis of autoimmune enteropathy and refractory sprue (coeliac disease)
  • Severe villous atrophy non-refractive to dietary restriction with circulating gut autoantibodies and/or associated autoimmune conditions, with a lack of severe immunodeficiency


Reference Range

Negative


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
28 days


Notes
Not currently performed in house; this test is referred to the Protein Reference Unit, Sheffield.

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