Imperial Collage Healthcare

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DNA double stranded antibodies, quantitative

Lab Code : DSDE

Test Background
Detection and quantitation of DNA is useful in the diagnosis of SLE and is more specific than the antinuclear antibody test. It is positive in about 50 % of cases of SLE. Low titres of anti-dsDNA can be present in normal individuals, and in patients with Sjögren's syndrome, rheumatoid arthritis and other disorders. The presence of anti-dsDNA tends to correlate with lupus nephritis, and the anti-dsDNA level often, but not always, correlates with disease activity in SLE.

Clinical Indications
Diagnosis of SLE Monitoring of SLE

Reference Range
<30 IU/mL

Sample Required
RST (rust top)

Sample Volume
5-10 mL (1 mL serum)

Turnaround Time
10 days

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