Imperial Collage Healthcare

Centromere antibodies


Test Background
These antibodies are found in a sub-group of scleroderma patients with the limited cutaneous form of the disease or CREST syndrome (calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia). It is also seen in patients with primary biliary cirrhosis (8-31 %).


Clinical Indications
Symptoms associated with systemic sclerosis, including skin involvement, Raynaud’s phenomenon and arthralgias.


Reference Range

Negative


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
4 days


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