Test Background These autoantibodies are directed against cardiolipin, a phosphorylated polysaccharide ester of fatty acids found in cell membranes. They are associated with immune-mediated illnesses such as antiphospholipid syndrome, vasculitis, Behçet’s syndrome, idiopathic spontaneous abortion and SLE. They are thought to be associated with a hypercoagulable state. Cardiolipin antibodies can often be observed during the convalescent phase of acute bacterial and viral infections, and in individuals with syphilis. These infection-induced antibodies are usually transient and are not associated with an increased risk of clinical complications. In general, all patients who test positive should be retested after 6 to 8 weeks to rule out transient antibodies that are usually of no clinical significance.
Clinical Indications Assessment and diagnosis of: vascular thrombosis and/or recurrent fetal loss thrombocytopenia heart valve disease nephropathy and neurological disease.
Reference Range Negative
Sample Required RST (rust top)
Sample Volume 5-10 mL (1 mL serum)
Turnaround Time 7 days. Additional confirmatory tests: 14 days.