Imperial Collage Healthcare

Antinuclear antibody screen


Test Background
Commonly positive at high titre (>1:640) in patients with SLE and other connective tissue diseases. The presence of ANA is indicative of SLE (present in 80-90 % of cases) although they also appear in some other autoimmune diseases, such as Sjögren’s syndrome (60 %), rheumatoid arthritis, autoimmune hepatitis, scleroderma and poly/dermatomyositis, Hashimoto’s disease and autoimmune haemolytic anaemia. Weak positive reactions are not uncommon and may have no clinical significance.


Clinical Indications

  • ANA should be requested for investigations of suspected connective tissue autoimmune syndromes. Autoantibody screening should be reserved for investigations where there is suspected liver involvement and/or anaemia. Autoimmune symptoms are typically variable and include:
  • painful or swollen joints
  • unexplained fever
  • back pain
  • extreme fatigue
  • rashes


Reference Range

Negative


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
4 days


Filter by A-Z

Select a test from the left to view more details.