Commonly positive at high titre (>1:640) in patients with SLE and other connective tissue diseases. The presence of ANA is indicative of SLE (present in 80-90 % of cases) although they also appear in some other autoimmune diseases, such as Sjögren’s syndrome (60 %), rheumatoid arthritis, autoimmune hepatitis, scleroderma and poly/dermatomyositis, Hashimoto’s disease and autoimmune haemolytic anaemia. Weak positive reactions are not uncommon and may have no clinical significance.
RST (rust top)
5-10 mL (1 mL serum)