Imperial Collage Healthcare

Adrenal cortex antibodies


Test Background
Anti-adrenal antibody results are positive in 60-70 % of patients with idiopathic Addison’s disease. Antibodies against adrenal cortex are associated with primary adrenal failure in up to 50 % of patients with Addisonian adrenal insufficiency. Positive antibodies can, however, be an incidental finding or predate the development of hypoadrenalism.
Anti-adrenal antibodies are also present in 28 % of patients with idiopathic hypothyroidism and 7 % of patients with Hashimoto’s disease.
Positive antibodies may also be associated with gonadal failure.


Clinical Indications
Raised titres in adrenocortical insufficiency due to an autoimmune disorder (Addison's Disease).


Reference Range

Negative


Sample Required
RST (rust top)


Sample Volume
5-10 mL (1 mL serum)


Turnaround Time
14 days


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